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eISSN: 1734-4948
ISSN: 0860-6161
Advances in Rehabilitation
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
 
4/2022
vol. 36
 
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abstract:
Original article

Effect of high-intensity interval training versus moderate-intensity continuous training on plasminogen activator inhibitor-1 in Type 2 diabetic women

Ahmad Mahdi Ahmad
1
,
Faten Ali
2
,
Heba Mohammed Ali
3

1.
Department of Physical Therapy for Cardiovascular and Respiratory Disorders, Faculty of Physical Therapy, Cairo University, Giza, Egypt
2.
Department of Physical Therapy for Internal Medicine and Geriatrics, Faculty of Physical Therapy, Delta University for Science and Technology, Dakahlia, Egypt
3.
Department of Physical Therapy for Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Beni-Suef University, Beni-Suef, Egypt
Advances in Rehabilitation, 2022, 36(4), 17–23
Online publish date: 2022/12/08
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Introduction
Elevated plasminogen activator inhibitor-1 (PAI-1) relates to thrombotic events in Type 2 diabetes. This study aimed to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on PAI-1 in type 2 diabetic women.

Material and methods
Twenty six type 2 diabetic women were assigned to two groups and data for eighteen was analyzed: HIIT group (n=8, 42.1±6.8 yrs, 33.1±4.95 kg/m2) and MICT group (n=10, 41.1±2.9 yrs, 35.2±2.6 kg/m2). Outcome measures were PAI-1, glycosylated hemoglobin (HbA1c), and body mass index (BMI). The HIIT group performed 4 x 4-min working phases at 85%–90% of peak HR (heart rate), followed by 3-min active rest intervals. At 65%–75% of peak HR, the MICT group exercised for 30 minutes. Both exercise interventions included a warm-up and a cool-down period and were performed on a treadmill for 8 weeks.

Results
HIIT group showed significant reductions in PAI-1 (29.09 ± 2.67 vs. 37.42 ± 3.52 ng/mL, p< 0.001) and HBA1c (6.45 ± 0.50 vs. 8.34 ± 0.44 %, p<0.001) compared to baseline. Also, MICT group showed significant reductions in PAI-1 (30.37 ± 2.92 vs. 38.49 ± 2.40 ng/mL, p<0.001) and HbA1c (6.78 ± 0.36 vs. 8.15 ± 0.63 %, p<0.001) compared to baseline. Non-significant differences were found in these outcomes between groups. BMI was not significantly changed in either group.

Conclusions
The MICT could be as effective as HIIT for reducing elevated PAI-1 and HbA1c levels in obese women with type 2 diabetes, regardless of BMI changes. The less vigorous MICT could be suggested in this patient population to improve fibrinolysis and hyperglycemia.

keywords:

body mass, exercise, fibrinolysis, hyperglycemia index, type 2 diabetes











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